Association between COL1A1 polymorphisms and high myopia: a meta-analysis.

BACKGROUND Previous studies of the association between COL1A1 polymorphisms and high myopia risk have yielded conflicting results. To help resolve the discrepancies, we performed a meta-analysis to estimate the relationship between COL1A1 polymorphisms and high myopia risk. METHODS We searched for case-control and cohort studies in MEDLINE, EMBASE, and OVID. Odds ratios (OR) with 95% confidence intervals (CI) were derived for single-nucleotide polymorphisms (SNPs). We also analyzed heterogeneity and publication bias. RESULTS This meta-analysis was based on five studies of rs2075555 (1,944 high myopia cases and 3,060 controls), and three studies of rs2269336 (1,454 high myopia cases and 1,512 controls). The combined results showed an association between rs2075555 and high myopia in the dominant (OR = 0.86, 95% CI = 0.71-0.99) and homozygote models (OR = 0.79, 95% CI = 0.64-0.97). In the recessive model for rs2269336, OR was 1.26 (95% CI = 1.05-1.50); in the heterozygote model, OR was 0.81 (95% CI = 0.69-0.96). Begg's and Egger's tests for rs2075555 showed no evidence of publication bias. CONCLUSIONS This meta-analysis suggests COL1A1 rs2075555 is a potential low risk factor for high myopia.